![]() ![]() However, a twofold rise in BMD-Condalab MICs which was detected in 50% of the isolates, resulted in changes in susceptibility categories of few isolates with MICs close to susceptibility breakpoints leading to an overall minor error (MI) rate of 4.7%. ![]() ![]() MICs determined by BMD using MHB from two suppliers showed a good correlation with overall essential agreement (EA) and categorical agreement (CA) being 100% and 95% respectively. FDA TGC susceptibility breakpoints issued for Enterobacteriaceae were used for interpretation of the results. The TGC susceptibility of 84 clinical isolates of Klebsiella pneumoniae ( n = 29), Escherichia coli ( n = 30), and Acinetobacter baumannii ( n = 25) was tested by broth microdilution (BMD), Etest, agar dilution (AD) and disk diffusion (DD) methods using Mueller Hinton agar from Difco and Mueller Hinton broth (MHB) from two different manufacturers (Difco and Condalab). ![]() We evaluated the influence of different methodologies and type of media on TGC susceptibility of different gram-negative bacteria of clinical origin. Availability of reliable methods for testing TGC susceptibility is crucial to accurately predict clinical outcomes. The current emergence of multi-drug resistance among nosocomial pathogens has led to increased use of last-resort agents including Tigecycline (TGC). ![]()
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